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When radiolabelled clenbuterol was given orally to pregnant rats, dogs, baboons and cattle, radioactivity was detected in the fetuses. Clenbuterol was moderately toxic in mice and rats after oral administration, LD 50 values being in the range of 80-175 mg/kg bw. Beta(2)-receptor adrenergic agonists as clenbuterol and analogues are illegally used as growth promoters in cattle, in Europe, as well as in other countries. The Bottom Line Clenbuterol is a medication used to treat asthma and COPD in some countries, but it is not FDA-approved for human use in the United States. It is widely misused for possible anabolic and fat-burning effects, which have only been shown in animals. Clenbuterol causes toxicity at low doses. [Toxicological effects of clenbuterol in human and animals] It is reported that clenbuterol increases the lean- to fat conversion in livestock and is an illegal stimulating and growth promoter. Sympathomimetic effects due to beta agonism: restlessness/ anxiety, headache, diaphoresis, tachycardia, tachypnoea, tachyarrhythmias, hypertension. Metabolic effects: hypokalaemia, hyperglycaemia, less commonly hypoglycaemia, hypomagnesaemia, hypophosphataemia. Clenbuterol is used as a bronchodilator for horses and non-lactating cattle. The recommended treatment schedule is 0. 8 m g/kg BW twice daily. The maximum duration of treatment in non-lactating cattle is 10 days. It may be administered by the oral or intravenous routes of administration. Cattle may also be injected by the intramuscular route Instead, it boosts your body’s natural energy production, so you feel naturally energized and alert, cattle clenbuterol toxic.
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